KCNK12 (potassium two pore domain channel subfamily K member 12)

2014-11-01  

Identity

HGNC
KCNK12
LOCATION
2p16.3
LOCUSID
56660
ALIAS
K2p12.1,THIK-2,THIK2

Other Information

Locus ID:

NCBI: 56660
MIM: 607366
HGNC: 6274
Ensembl: ENSG00000184261

Variants:

dbSNP: 56660
ClinVar: 56660
TCGA: ENSG00000184261
COSMIC: KCNK12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184261ENST00000327876Q9HB15

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 4 - resting membrane potentialREACTOMER-HSA-5576886

References

Pubmed IDYearTitleCitations
186769882008A high-density association screen of 155 ion transport genes for involvement with common migraine.22
251486872014Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.12
241633672013Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.9
182094732008Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.4

Citation

Dessen P

KCNK12 (potassium two pore domain channel subfamily K member 12)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64794/kcnk12