KCNK16 (potassium two pore domain channel subfamily K member 16)

2014-11-01  

Identity

HGNC
LOCATION
6p21.2
LOCUSID
ALIAS
K2p16.1,TALK-1,TALK1

Other Information

Locus ID:

NCBI: 83795
MIM: 607369
HGNC: 14464
Ensembl: ENSG00000095981

Variants:

dbSNP: 83795
ClinVar: 83795
TCGA: ENSG00000095981
COSMIC: KCNK16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000095981ENST00000373227Q96T55
ENSG00000095981ENST00000373229Q96T55
ENSG00000095981ENST00000425054Q96T55
ENSG00000095981ENST00000437525Q96T55
ENSG00000095981ENST00000507712D6RC57

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Tandem pore domain potassium channelsREACTOMER-HSA-1296346
TWIK-related alkaline pH activated K+ channel (TALK)REACTOMER-HSA-1299361
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 4 - resting membrane potentialREACTOMER-HSA-5576886

References

Pubmed IDYearTitleCitations
262390562015Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.18
127241422003Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.8
284031692017Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells.4
289282382017TALK-1 channels control β cell endoplasmic reticulum Ca2+ homeostasis.3

Citation

Dessen P

KCNK16 (potassium two pore domain channel subfamily K member 16)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64797/kcnk16