KCNK2 (potassium two pore domain channel subfamily K member 2)

2014-06-01  

Identity

HGNC
KCNK2
LOCATION
1q41
LOCUSID
3776
ALIAS
K2p2.1,TPKC1,TREK,TREK-1,TREK1,hTREK-1c,hTREK-1e
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3776
MIM: 603219
HGNC: 6277
Ensembl: ENSG00000082482

Variants:

dbSNP: 3776
ClinVar: 3776
TCGA: ENSG00000082482
COSMIC: KCNK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000082482ENST00000391894O95069
ENSG00000082482ENST00000391894U3N6F0
ENSG00000082482ENST00000391895O95069
ENSG00000082482ENST00000391895U3N834
ENSG00000082482ENST00000444842O95069
ENSG00000082482ENST00000457122C9JXY2
ENSG00000082482ENST00000467031O95069
ENSG00000082482ENST00000470177B4DGU6
ENSG00000082482ENST00000474771F8WDE6
ENSG00000082482ENST00000478774C9JDK1
ENSG00000082482ENST00000486921Q6ZW95

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gastric acid secretionKEGGko04971
Gastric acid secretionKEGGhsa04971
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Tandem pore domain potassium channelsREACTOMER-HSA-1296346
TWIK related potassium channel (TREK)REACTOMER-HSA-1299503
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 4 - resting membrane potentialREACTOMER-HSA-5576886

References

Pubmed IDYearTitleCitations
173750392007The neuronal background K2P channels: focus on TREK1.157
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
218222182011The pore structure and gating mechanism of K2P channels.60
156852122005Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine.56
160065632005Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels.50
239339812013Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS.44
182880902008Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study.38
182880902008Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study.38

Citation

Dessen P

KCNK2 (potassium two pore domain channel subfamily K member 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53934/kcnk2