KCNK9 (potassium two pore domain channel subfamily K member 9)

2007-02-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
BIBARS,K2p9.1,KT3.2,TASK-3,TASK3,TASK32
FUSION GENES

Other Information

Locus ID:

NCBI: 51305
MIM: 605874
HGNC: 6283
Ensembl: ENSG00000169427

Variants:

dbSNP: 51305
ClinVar: 51305
TCGA: ENSG00000169427
COSMIC: KCNK9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169427ENST00000303015Q9NPC2
ENSG00000169427ENST00000303015A0A024R9H3
ENSG00000169427ENST00000520439Q9NPC2
ENSG00000169427ENST00000520439A0A024R9H3
ENSG00000169427ENST00000522317Q9NPC2
ENSG00000169427ENST00000522317A0A024R9H3
ENSG00000169427ENST00000647605A0A3B3ITR0
ENSG00000169427ENST00000648164Q9NPC2
ENSG00000169427ENST00000648164A0A024R9H3
ENSG00000169427ENST00000649473A0A3B3IU12
ENSG00000169427ENST00000649696A0A3B3ITR0
ENSG00000169427ENST00000650269Q9NPC2
ENSG00000169427ENST00000650269A0A024R9H3

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Tandem pore domain potassium channelsREACTOMER-HSA-1296346
TWIK-releated acid-sensitive K+ channel (TASK)REACTOMER-HSA-1299316
Muscle contractionREACTOMER-HSA-397014
Aldosterone synthesis and secretionKEGGhsa04925
Aldosterone synthesis and secretionKEGGko04925
Cardiac conductionREACTOMER-HSA-5576891
Phase 4 - resting membrane potentialREACTOMER-HSA-5576886

References

Pubmed IDYearTitleCitations
126765872003Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
118868612002Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) potassium channels: volatile anesthetics and neurotransmitters share a molecular site of action.55
186783202008Maternally inherited Birk Barel mental retardation dysmorphism syndrome caused by a mutation in the genomically imprinted potassium channel KCNK9.52
127827912003Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function.40
183759522008TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 critically influence T lymphocyte effector functions.30
264809202016Genome-wide association studies suggest sex-specific loci associated with abdominal and visceral fat.30
175476992007A di-acidic sequence motif enhances the surface expression of the potassium channel TASK-3.27
254205092014Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors.26
152843502004Selective block of the human 2-P domain potassium channel, TASK-3, and the native leak potassium current, IKSO, by zinc.23

Citation

Dessen P

KCNK9 (potassium two pore domain channel subfamily K member 9)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43764/kcnk9