KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1)
2003-08-01 AffiliationIdentity
HGNC
LOCATION
5q35.1
LOCUSID
ALIAS
BKbeta1,K(VCA)beta,SLO-BETA,hbeta1,hslo-beta,k(VCA)beta-1,slo-beta-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3779
MIM: 603951
HGNC: 6285
Ensembl: ENSG00000145936
Variants:
dbSNP: 3779
ClinVar: 3779
TCGA: ENSG00000145936
COSMIC: KCNMB1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000145936 | ENST00000274629 | Q16558 |
| ENSG00000145936 | ENST00000521859 | Q16558 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443796 | Coronary Artery Disease | Disease | ClinicalAnnotation | associated | PD | 17700361 | |
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 17700361, 18496125, 18854753 | |
| PA451868 | verapamil | Chemical | ClinicalAnnotation | associated | PD | 17700361, 18496125, 18854753 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31486669 | 2020 | The Role of KCNMB1 and BK Channels in Myofibroblast Differentiation and Pulmonary Fibrosis. | 18 |
| 31486669 | 2020 | The Role of KCNMB1 and BK Channels in Myofibroblast Differentiation and Pulmonary Fibrosis. | 18 |
| 29850792 | 2019 | Downregulation of BK channel function and protein expression in coronary arteriolar smooth muscle cells of type 2 diabetic patients. | 10 |
| 29850792 | 2019 | Downregulation of BK channel function and protein expression in coronary arteriolar smooth muscle cells of type 2 diabetic patients. | 10 |
| 28429615 | 2017 | Regulation of vascular large-conductance calcium-activated potassium channels by Nrf2 signalling. | 13 |
| 28750098 | 2017 | The unique N-terminal sequence of the BKCa channel α-subunit determines its modulation by β-subunits. | 2 |
| 28429615 | 2017 | Regulation of vascular large-conductance calcium-activated potassium channels by Nrf2 signalling. | 13 |
| 28750098 | 2017 | The unique N-terminal sequence of the BKCa channel α-subunit determines its modulation by β-subunits. | 2 |
| 27217576 | 2016 | β1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel. | 9 |
| 27217576 | 2016 | β1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel. | 9 |
| 25576871 | 2015 | 7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels. | 1 |
| 25825713 | 2015 | Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels. | 15 |
| 25576871 | 2015 | 7-Ketocholesterol induces the reduction of KCNMB1 in atherosclerotic blood vessels. | 1 |
| 25825713 | 2015 | Molecular mechanism underlying β1 regulation in voltage- and calcium-activated potassium (BK) channels. | 15 |
| 24476761 | 2014 | Bisphenol A activates BK channels through effects on α and β1 subunits. | 5 |
Citation
Dessen P
KCNMB1 (potassium calcium-activated channel subfamily M regulatory beta subunit 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/41050/kcnmb1
