KCNN3 (potassium calcium-activated channel subfamily N member 3)

2010-02-01  

Identity

HGNC
LOCATION
1q21.3
LOCUSID
ALIAS
KCa2.3,SK3,SKCA3,ZLS3,hSK3
FUSION GENES

Other Information

Locus ID:

NCBI: 3782
MIM: 602983
HGNC: 6292
Ensembl: ENSG00000143603

Variants:

dbSNP: 3782
ClinVar: 3782
TCGA: ENSG00000143603
COSMIC: KCNN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143603ENST00000271915Q9UGI6
ENSG00000143603ENST00000358505Q9UGI6
ENSG00000143603ENST00000361147Q9UGI6
ENSG00000143603ENST00000618040A0A087WYJ0

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Insulin secretionKEGGhsa04911
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Ca2+ activated K+ channelsREACTOMER-HSA-1296052

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
201737472010Common variants in KCNN3 are associated with lone atrial fibrillation.200
201737472010Common variants in KCNN3 are associated with lone atrial fibrillation.200
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
257308482015SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx.121
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
237742102013Pivotal role of the lipid Raft SK3-Orai1 complex in human cancer cell migration and bone metastases.58
271024342016SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline.34
145599172004The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system.32
124572342002Kit-negative fibroblast-like cells expressing SK3, a Ca2+-activated K+ channel, in the gut musculature in health and disease.31
204680642010Association study of 182 candidate genes in anorexia nervosa.30

Citation

Dessen P

KCNN3 (potassium calcium-activated channel subfamily N member 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51331/kcnn3