KDM1A (lysine demethylase 1A)

2009-10-01  

Identity

HGNC
KDM1A
LOCATION
1p36.12
LOCUSID
23028
ALIAS
AOF2,BHC110,CPRF,KDM1,LSD1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23028
MIM: 609132
HGNC: 29079
Ensembl: ENSG00000004487

Variants:

dbSNP: 23028
ClinVar: 23028
TCGA: ENSG00000004487
COSMIC: KDM1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000004487ENST00000356634O60341
ENSG00000004487ENST00000400181O60341
ENSG00000004487ENST00000465864R4GMQ1
ENSG00000004487ENST00000494920R4GMP9

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3REACTOMER-HSA-5625886
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815
HDMs demethylate histonesREACTOMER-HSA-3214842

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
156203532004Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.1226
206162352010Long noncoding RNA as modular scaffold of histone modification complexes.1192
160797952005LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription.570
161400332005Regulation of LSD1 histone demethylase activity by its associated factors.324
160797942005An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation.286
178052992007p53 is regulated by the lysine demethylase LSD1.262
197033932009LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer.236
172777722007Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.226
176873282007Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression.191
224648002012The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells.188

Citation

Dessen P

KDM1A (lysine demethylase 1A)

Atlas Genet Cytogenet Oncol Haematol. 2009-10-01

Online version: http://atlasgeneticsoncology.org/gene/51150/kdm1a