KDM6B (lysine demethylase 6B)

2009-05-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
JMJD3,NEDCFSA
FUSION GENES

Other Information

Locus ID:

NCBI: 23135
MIM: 611577
HGNC: 29012
Ensembl: ENSG00000132510

Variants:

dbSNP: 23135
ClinVar: 23135
TCGA: ENSG00000132510
COSMIC: KDM6B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132510ENST00000254846O15054
ENSG00000132510ENST00000448097O15054
ENSG00000132510ENST00000570632I3L0Z0

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177134782007UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.464
180039142007Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.230
194512172009The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence.177
186283932008Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3.123
212452942011Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming.101
227702412012Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.97
179238642007JMJD3 is a histone H3K27 demethylase.86
225897172012KSHV PAN RNA associates with demethylases UTX and JMJD3 to activate lytic replication through a physical interaction with the virus genome.75
227138732012The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.67
231524972012Histone demethylase KDM6B promotes epithelial-mesenchymal transition.58

Citation

Dessen P

KDM6B (lysine demethylase 6B)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50868/kdm6b