KDM8 (lysine demethylase 8)

2009-03-01  

Identity

HGNC
KDM8
LOCATION
16p12.1
LOCUSID
79831
ALIAS
JMJD5

Other Information

Locus ID:

NCBI: 79831
MIM: 611917
HGNC: 25840
Ensembl: ENSG00000155666

Variants:

dbSNP: 79831
ClinVar: 79831
TCGA: ENSG00000155666
COSMIC: KDM8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155666ENST00000286096Q8N371
ENSG00000155666ENST00000286096A0A0S2Z5T1
ENSG00000155666ENST00000441782Q8N371
ENSG00000155666ENST00000562733H3BM39
ENSG00000155666ENST00000567735H3BPT5
ENSG00000155666ENST00000568965Q8N371
ENSG00000155666ENST00000569329H3BR76

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
243443052014JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.93
168584122006Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice.71
211158192010Jumonji domain protein JMJD5 functions in both the plant and human circadian systems.65
204578932010KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation.58
223750082012JMJD5, a Jumonji C (JmjC) domain-containing protein, negatively regulates osteoclastogenesis by facilitating NFATc1 protein degradation.22
228516972012Crystal structure and functional analysis of JMJD5 indicate an alternate specificity and function.21
247409262014JMJD5 regulates cell cycle and pluripotency in human embryonic stem cells.19
249818602014Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.18
288479612017Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.11
289829402017JMJD5 cleaves monomethylated histone H3 N-tail under DNA damaging stress.11

Citation

Dessen P

KDM8 (lysine demethylase 8)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50701/kdm8