KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3)

2007-02-01  

Identity

HGNC
KHDRBS3
LOCATION
8q24.23
LOCUSID
10656
ALIAS
Etle,SALP,SLM-2,SLM2,T-STAR,TSTAR,etoile
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10656
MIM: 610421
HGNC: 18117
Ensembl: ENSG00000131773

Variants:

dbSNP: 10656
ClinVar: 10656
TCGA: ENSG00000131773
COSMIC: KHDRBS3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131773ENST00000355849O75525
ENSG00000131773ENST00000517394E5RG12
ENSG00000131773ENST00000517859H0YAQ3
ENSG00000131773ENST00000520981E5RHD3
ENSG00000131773ENST00000521461H0YB45
ENSG00000131773ENST00000524199E5RJZ9
ENSG00000131773ENST00000524282H0YAQ1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by PTK6REACTOMER-HSA-8848021
PTK6 Regulates Proteins Involved in RNA ProcessingREACTOMER-HSA-8849468

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
195849242009Amplification and overexpression of Hsa-miR-30b, Hsa-miR-30d and KHDRBS3 at 8q24.22-q24.23 in medulloblastoma.46
267580682016Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68.21
159017632005Sam68-like mammalian protein 2, identified by digital differential display as expressed by podocytes, is induced in proteinuria and involved in splice site selection of vascular endothelial growth factor.9
293563992018SALL4 - KHDRBS3 network enhances stemness by modulating CD44 splicing in basal-like breast cancer.7
217256122011SerpinB5 interacts with KHDRBS3 and FBXO32 in gastric cancer cells.6
168107592006Expression of T-STAR gene is associated with regulation of telomerase activity in human colon cancer cell line HCT-116.5
239230072013Nuclear T-STAR protein expression correlates with HER2 status, hormone receptor negativity and prolonged recurrence free survival in primary breast cancer and decreased cancer cell growth in vitro.1
129216302003[Association of child absence epilepsy with T-STAR gene].0
288719472017[Knock-down of KHDRBS3 gene inhibits proliferation of human ovarian cancer CAOV-3 cells].0

Citation

Dessen P

KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43701/khdrbs3