KIAA1549 (KIAA1549)

2012-03-01  

Identity

HGNC
LOCATION
7q34
LOCUSID
ALIAS
RP86
FUSION GENES

Other Information

Locus ID:

NCBI: 57670
MIM: 613344
HGNC: 22219
Ensembl: ENSG00000122778

Variants:

dbSNP: 57670
ClinVar: 57670
TCGA: ENSG00000122778
COSMIC: KIAA1549

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122778ENST00000422774Q9HCM3
ENSG00000122778ENST00000440172Q9HCM3

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
221576202012BRAF alterations in primary glial and glioneuronal neoplasms of the central nervous system with identification of 2 novel KIAA1549:BRAF fusion variants.55
216964152011BRAF-KIAA1549 fusion transcripts are less frequent in pilocytic astrocytomas diagnosed in adults.26
260835712015KIAA1549: BRAF Gene Fusion and FGFR1 Hotspot Mutations Are Prognostic Factors in Pilocytic Astrocytomas.19
225914442012KIAA1549-BRAF fusions and IDH mutations can coexist in diffuse gliomas of adults.10
245292092014Posterior fossa and spinal gangliogliomas form two distinct clinicopathologic and molecular subgroups.10
245322632014Analysis of KIAA1549-BRAF fusion gene expression and IDH1/IDH2 mutations in low grade pediatric astrocytomas.9
261159612016Analysis of IDH1-R132 mutation, BRAF V600 mutation and KIAA1549-BRAF fusion transcript status in central nervous system tumors supports pediatric tumor classification.9
257944452015Oncogenic KIAA1549-BRAF fusion with activation of the MAPK/ERK pathway in pediatric oligodendrogliomas.8

Citation

Dessen P

KIAA1549 (KIAA1549)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52621/kiaa1549