KIDINS220 (kinase D interacting substrate 220)

2008-01-01 Affiliation

Identity

HGNC

KIDINS220

LOCATION

2p25.1

LOCUSID

57498

ALIAS

ARMS,SINO

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 57498
MIM: 615759
HGNC: 29508
Ensembl: ENSG00000134313

Variants:

dbSNP: 57498
ClinVar: 57498
TCGA: ENSG00000134313
COSMIC: KIDINS220

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000134313	ENST00000256707	Q9ULH0
ENSG00000134313	ENST00000319688	Q9ULH0
ENSG00000134313	ENST00000459813	H7C584
ENSG00000134313	ENST00000473731	Q9ULH0
ENSG00000134313	ENST00000488729	F8WAY8
ENSG00000134313	ENST00000489024	E9PH70
ENSG00000134313	ENST00000496383	H0Y8E4
ENSG00000134313	ENST00000569008	A0A1W2PPB7
ENSG00000134313	ENST00000638224	A0A1W2PPY4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
Signal Transduction	REACTOME	R-HSA-162582
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Prolonged ERK activation events	REACTOME	R-HSA-169893
ARMS-mediated activation	REACTOME	R-HSA-170984

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18539593	2008	Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells.	43
22562556	2012	Kidins220/ARMS as a functional mediator of multiple receptor signalling pathways.	22
18048355	2008	PKD1, PKD2, and their substrate Kidins220 regulate neurotensin secretion in the BON human endocrine cell line.	21
23359496	2013	Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells.	15
18089783	2007	ARMS depletion facilitates UV irradiation induced apoptotic cell death in melanoma.	12
23118350	2013	Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3β/PP1 imbalance.	9
18501627	2008	Ankyrin-rich membrane spanning protein plays a critical role in nuclear factor-kappa B signaling.	8
21381019	2011	The neuronal protein Kidins220/ARMS associates with ICAM-3 and other uropod components and regulates T-cell motility.	8
23999075	2013	Kidins220/ARMS is expressed in neuroblastoma tumors and stabilizes neurotrophic signaling in a human neuroblastoma cell line.	7
23333500	2013	Kidins220/ARMS depletion is associated with the neural-to Schwann-like transition in a human neuroblastoma cell line model.	6

Citation

Dessen P

KIDINS220 (kinase D interacting substrate 220)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49984/kidins220