KIF11 (kinesin family member 11)

2007-02-01  

Identity

HGNC
LOCATION
10q23.33
LOCUSID
ALIAS
EG5,HKSP,KNSL1,MCLMR,TRIP5
FUSION GENES

Other Information

Locus ID:

NCBI: 3832
MIM: 148760
HGNC: 6388
Ensembl: ENSG00000138160

Variants:

dbSNP: 3832
ClinVar: 3832
TCGA: ENSG00000138160
COSMIC: KIF11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138160ENST00000260731P52732

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
172938762007A genome-wide association study identifies novel risk loci for type 2 diabetes.990
166040652006Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro.111
178274002007Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.97
198623252009PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.70
198623252009PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.70
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
200188972010ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism.66
216429572011Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.57
156653802005Monastrol inhibition of the mitotic kinesin Eg5.56
215221282011Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1.47

Citation

Dessen P

KIF11 (kinesin family member 11)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43858/kif11