KIF17 (kinesin family member 17)

2014-11-01  

Identity

HGNC
LOCATION
1p36.12
LOCUSID
ALIAS
KIF17B,KIF3X,KLP-2,OSM-3

Other Information

Locus ID:

NCBI: 57576
MIM: 605037
HGNC: 19167
Ensembl: ENSG00000117245

Variants:

dbSNP: 57576
ClinVar: 57576
TCGA: ENSG00000117245
COSMIC: KIF17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117245ENST00000247986Q9P2E2
ENSG00000117245ENST00000375044A0A0A0MRS8
ENSG00000117245ENST00000400463Q9P2E2

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Intraflagellar transportREACTOMER-HSA-5620924

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
205302082010Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms.51
206967102010KIF17 stabilizes microtubules and contributes to epithelial morphogenesis by acting at MT plus ends with EB1 and APC.45
203786152010Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.40
146730852003The kinesin KIF17b and RNA-binding protein TB-RBP transport specific cAMP-responsive element modulator-regulated mRNAs in male germ cells.25
280776222017Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal.17
287610022017Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load.15
206466812010De novo truncating mutation in Kinesin 17 associated with schizophrenia.12
268230182016Septin 9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport.11
240727172013Direct regulation of microtubule dynamics by KIF17 motor and tail domains.10

Citation

Dessen P

KIF17 (kinesin family member 17)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64914/kif17