KIF2C (kinesin family member 2C)

2003-08-01  

Identity

HGNC
KIF2C
LOCATION
1p34.1
LOCUSID
11004
ALIAS
CT139,KNSL6,MCAK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11004
MIM: 604538
HGNC: 6393
Ensembl: ENSG00000142945

Variants:

dbSNP: 11004
ClinVar: 11004
TCGA: ENSG00000142945
COSMIC: KIF2C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142945ENST00000372217Q99661
ENSG00000142945ENST00000372224Q99661
ENSG00000142945ENST00000372224A0A140VKF1
ENSG00000142945ENST00000423289H0Y5Z9
ENSG00000142945ENST00000452259Q5JR91
ENSG00000142945ENST00000455186Q5JR89

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

References

Pubmed IDYearTitleCitations
166729732006The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends.182
190608942009Genome stability is ensured by temporal control of kinetochore-microtubule dynamics.171
175380142007The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.100
153028532004The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK.94
162430292005Efficient mitosis in human cells lacking poleward microtubule flux.79
158831932005MCAK associates with the tips of polymerizing microtubules.68
208897152010Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres.61
218203092011A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases.55
238911082013Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK.42
179449722008Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis.40

Citation

Dessen P

KIF2C (kinesin family member 2C)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41069/kif2c