KIF3A (kinesin family member 3A)

2015-03-01  

Identity

HGNC
KIF3A
LOCATION
5q31.1
LOCUSID
11127
ALIAS
FLA10,KLP-20
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11127
MIM: 604683
HGNC: 6319
Ensembl: ENSG00000131437

Variants:

dbSNP: 11127
ClinVar: 11127
TCGA: ENSG00000131437
COSMIC: KIF3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131437ENST00000378735J3KPF9
ENSG00000131437ENST00000378746Q9Y496
ENSG00000131437ENST00000403231E9PES4
ENSG00000131437ENST00000428744C9J9X2
ENSG00000131437ENST00000450441H7C2F6
ENSG00000131437ENST00000618515A0A087X011

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hedgehog signaling pathwayKEGGko04340
Hedgehog signaling pathwayKEGGhsa04340
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Intraflagellar transportREACTOMER-HSA-5620924
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'off' stateREACTOMER-HSA-5610787
Hedgehog 'on' stateREACTOMER-HSA-5632684
Activation of SMOREACTOMER-HSA-5635838
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
189575122008The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling.79
162627232005Kinesin-2 is a motor for late endosomes and lysosomes.60
192829702009Kaposi's sarcoma-associated herpesvirus ORF45 interacts with kinesin-2 transporting viral capsid-tegument complexes along microtubules.33
200660752009Left-right determination: involvement of molecular motor KIF3, cilia, and nodal flow.33
162989992006Role of the kinesin-2 family protein, KIF3, during mitosis.32
233860612013Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.27
219126042011Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences.25
255888312015The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.19
190434532009Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion.17
287610022017Intraflagellar transport velocity is governed by the number of active KIF17 and KIF3AB motors and their motility properties under load.15

Citation

Dessen P

KIF3A (kinesin family member 3A)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55104/kif3a