KIFC1 (kinesin family member C1)

2009-05-01  

Identity

HGNC
KIFC1
LOCATION
6p21.32
LOCUSID
3833
ALIAS
HSET,KNSL2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3833
MIM: 603763
HGNC: 6389
Ensembl: ENSG00000237649

Variants:

dbSNP: 3833
ClinVar: 3833
TCGA: ENSG00000237649
COSMIC: KIFC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000237649ENST00000428849Q9BW19
ENSG00000237649ENST00000428849A0A024RCS7
ENSG00000237649ENST00000450504A2AB20
ENSG00000237649ENST00000494554A0A087X1W5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
195259382009Chromosome congression in the absence of kinetochore fibres.73
191901322009The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain.60
191163092009Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules.59
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
229460582012Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET.30
257882772015HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients.24
261773312015KIFC1 is a novel potential therapeutic target for breast cancer.24
269876842016A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer.19
250285992014KIFCI, a novel putative prognostic biomarker for ovarian adenocarcinomas: delineating protein interaction networks and signaling circuitries.17
301159762019KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.16

Citation

Dessen P

KIFC1 (kinesin family member C1)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50878/kifc1