KIN (Kin17 DNA and RNA binding protein)

2006-10-01 Affiliation

Identity

HGNC

KIN

LOCATION

10p14

LOCUSID

22944

ALIAS

BTCD,KIN17,Rts2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 22944
MIM: 601720
HGNC: 6327
Ensembl: ENSG00000151657

Variants:

dbSNP: 22944
ClinVar: 22944
TCGA: ENSG00000151657
COSMIC: KIN

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000151657	ENST00000379562	O60870
ENSG00000151657	ENST00000498098	S4R357

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Protein methylation	REACTOME	R-HSA-8876725

References

Pubmed ID	Year	Title	Citations
23349634	2013	A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.	71
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
12525703	2003	Global genome repair is required to activate KIN17, a UVC-responsive gene involved in DNA replication.	16
11880372	2002	Ionizing radiation triggers chromatin-bound kin17 complex formation in human cells.	15
15831485	2005	The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins.	9
17045609	2006	A tandem of SH3-like domains participates in RNA binding in KIN17, a human protein activated in response to genotoxics.	9
21980430	2011	Up-regulation of kin17 is essential for proliferation of breast cancer.	8
12751957	2003	Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells.	6
12359749	2002	Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication.	5
18029424	2007	Solution structure of the region 51-160 of human KIN17 reveals an atypical winged helix domain.	4

Citation

Dessen P

KIN (Kin17 DNA and RNA binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43333/kin