KIR2DL4 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4)

2016-05-01  

Identity

HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
CD158D,G9P,KIR-103AS,KIR-2DL4,KIR103,KIR103AS

Other Information

Locus ID:

NCBI: 3805
MIM: 604945
HGNC: 6332
Ensembl: ENSG00000189013

Variants:

dbSNP: 3805
ClinVar: 3805
TCGA: ENSG00000189013
COSMIC: KIR2DL4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189013ENST00000345540Q99706
ENSG00000189013ENST00000345540A0A376A929
ENSG00000189013ENST00000346587Q8N736
ENSG00000189013ENST00000357494Q99706
ENSG00000189013ENST00000357494A0A376A8K3
ENSG00000189013ENST00000359085A0A0B4J1S6
ENSG00000189013ENST00000396284E7EST5
ENSG00000189013ENST00000396289A8MT18
ENSG00000189013ENST00000396293Q99706

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Natural killer cell mediated cytotoxicityKEGGko04650
Antigen processing and presentationKEGGhsa04612
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
189459622009Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.166
163667342006Activation of NK cells by an endocytosed receptor for soluble HLA-G.85
156709762005HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells.62
114899652001Cutting edge: induction of IFN-gamma production but not cytotoxicity by the killer cell Ig-like receptor KIR2DL4 (CD158d) in resting NK cells.61
120552342002KIR2DL4 (CD158d), an NK cell-activating receptor with inhibitory potential.58
145006362003KIR2DL4 is an IL-2-regulated NK cell receptor that exhibits limited expression in humans but triggers strong IFN-gamma production.58
125386632003DNA methylation maintains allele-specific KIR gene expression in human natural killer cells.57
193047992009HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells.54
157783392005Cutting edge: KIR2DL4 transduces signals into human NK cells through association with the Fc receptor gamma protein.50
231849842012Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling.50

Citation

Dessen P

KIR2DL4 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55769/kir2dl4