KIR2DS2 (killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2)

2009-09-01  

Identity

HGNC
KIR2DS2
LOCATION
19q13.42
LOCUSID
100132285
ALIAS
183ActI,CD158J,CD158b,KIR-2DS2,KIR2DL1,NKAT-5,NKAT5,cl-49

Other Information

Locus ID:

NCBI: 100132285
MIM: 604953
HGNC: 6334

Variants:

dbSNP: 100132285
ClinVar: 100132285
COSMIC: KIR2DS2

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Natural killer cell mediated cytotoxicityKEGGko04650
Antigen processing and presentationKEGGhsa04612
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164784024peginterferon alfa-2bChemicalMultilinkAnnotationassociated26975229

References

Pubmed IDYearTitleCitations
189459622009Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.166
233258342013NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.162
199342972009KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.50
172008712007KIR haplotype content at the allele level in 77 Northern Irish families.36
208784002010Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.32
198465352010Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection.31
151464262004Association of killer cell immunoglobulin-like receptors with scleroderma.30
153561182004Stimulatory killer Ig-like receptors modulate T cell activation through DAP12-dependent and DAP12-independent mechanisms.28
245502932014Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11.28
198611442010Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.22

Citation

Dessen P

KIR2DS2 (killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51106/kir2ds2