KIR3DS1 (killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1)

2013-05-01  

Identity

HGNC
LOCATION
19q13.42
LOCUSID
ALIAS
CD158E2,KIR-123FM,KIR-G1,NKAT-10,NKAT10

Other Information

Locus ID:

NCBI: 3813
HGNC: 6340

Variants:

dbSNP: 3813
ClinVar: 3813
COSMIC: KIR3DS1

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127

References

Pubmed IDYearTitleCitations
180251292007Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes.217
189459622009Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.166
233258342013NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.162
176940542007Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans.108
193867172009HLA class I subtype-dependent expansion of KIR3DS1+ and KIR3DL1+ NK cells during acute human immunodeficiency virus type 1 infection.99
183170002008Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals.70
183050352008Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection.58
199342972009KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.50
190089432008Genetic control of variegated KIR gene expression: polymorphisms of the bi-directional KIR3DL1 promoter are associated with distinct frequencies of gene expression.49
159429062005Protective effect of the HLA-Bw4I80 epitope and the killer cell immunoglobulin-like receptor 3DS1 gene against the development of hepatocellular carcinoma in patients with hepatitis C virus infection.45

Citation

Dessen P

KIR3DS1 (killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/51062/kir3ds1