Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9365
MIM: 604824
HGNC: 6344
Ensembl: ENSG00000133116
Variants:
dbSNP: 9365
ClinVar: 9365
TCGA: ENSG00000133116
COSMIC: KL
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000133116 | ENST00000380099 | Q9UEF7 |
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10832 | corticosteroids | Chemical | VariantAnnotation | associated | PD | 30697902 | |
| PA164712535 | Beta Blocking Agents | Chemical | ClinicalAnnotation | associated | PD | 31350855 | |
| PA443450 | Asthma | Disease | VariantAnnotation | associated | PD | 30697902 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37443358 | 2024 | FGF23 and klotho at the intersection of kidney and cardiovascular disease. | 9 |
| 37648906 | 2024 | The relationship between klotho, testosterone, and sexual health parameters among US adult men. | 2 |
| 37875141 | 2024 | The Relationship Between Serum Fibroblast Growth Factor 23 and Klotho Protein and Low Bone Mineral Density in Middle-Aged and Elderly Patients with End-Stage Renal Disease. | 0 |
| 38040805 | 2024 | Revealing the tumor suppressive sequence within KL1 domain of the hormone Klotho. | 0 |
| 38164143 | 2024 | Klotho-derived peptide 1 inhibits cellular senescence in the fibrotic kidney by restoring Klotho expression via posttranscriptional regulation. | 4 |
| 38169578 | 2024 | Beneficial effects of physical exercise on the osteo-renal Klotho-FGF-23 axis in Chronic Kidney Disease: A systematic review with meta-analysis. | 1 |
| 38169796 | 2024 | Interplay of Systemic Immune-Inflammation Index and Serum Klotho Levels: Unveiling a New Dimension in Rheumatoid Arthritis Pathology. | 0 |
| 38224227 | 2024 | Evaluation of klotho expression on peripheral blood lymphocytes among hemodialysis patients and its possible contribution to their immuno-compromised status. | 1 |
| 38339121 | 2024 | Soluble Klotho, a Potential Biomarker of Chronic Kidney Disease-Mineral Bone Disorders Involved in Healthy Ageing: Lights and Shadows. | 2 |
| 38342873 | 2024 | Association Between Klotho Gene Polymorphisms and Urolithiasis: A Meta-Analysis. | 0 |
| 38374169 | 2024 | Serum α-Klotho and fibroblast growth factor 23 levels are not associated with non-proliferative diabetic retinopathy in type 1 diabetes mellitus. | 0 |
| 38396063 | 2024 | Correlation between soluble klotho and chronic kidney disease-mineral and bone disorder in chronic kidney disease: a meta-analysis. | 0 |
| 38409304 | 2024 | The optimal cut-off values of Klotho for predicting all-cause and cardiovascular mortality among chronic kidney disease: results from NHANES. | 0 |
| 38459119 | 2024 | Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies. | 1 |
| 38501099 | 2024 | Serum klotho as a novel biomarker for metabolic syndrome: findings from a large national cohort. | 1 |
Citation
Dessen P
KL (klotho)
Atlas Genet Cytogenet Oncol Haematol. 2009-01-01
Online version: http://atlasgeneticsoncology.org/gene/50639/kl
