KLC1 (kinesin light chain 1)

2007-12-01  

Identity

HGNC
LOCATION
14q32.33
LOCUSID
ALIAS
KLC,KNS2,KNS2A
FUSION GENES

Other Information

Locus ID:

NCBI: 3831
MIM: 600025
HGNC: 6387
Ensembl: ENSG00000126214

Variants:

dbSNP: 3831
ClinVar: 3831
TCGA: ENSG00000126214
COSMIC: KLC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126214ENST00000246489Q07866
ENSG00000126214ENST00000334553Q07866
ENSG00000126214ENST00000347839Q07866
ENSG00000126214ENST00000348520Q07866
ENSG00000126214ENST00000380038F8W6L3
ENSG00000126214ENST00000389744Q07866
ENSG00000126214ENST00000445352G5E9S8
ENSG00000126214ENST00000452929Q07866
ENSG00000126214ENST00000535194H0YGB8
ENSG00000126214ENST00000537046H0YG16
ENSG00000126214ENST00000553286Q07866
ENSG00000126214ENST00000553325H0YJU9
ENSG00000126214ENST00000553436H0YJT3
ENSG00000126214ENST00000554228Q07866
ENSG00000126214ENST00000554280G3V3H3
ENSG00000126214ENST00000555836G3V5R9
ENSG00000126214ENST00000555856H0YJL0
ENSG00000126214ENST00000557172G3V2P7
ENSG00000126214ENST00000557450Q07866
ENSG00000126214ENST00000557575G3V2E7
ENSG00000126214ENST00000557686H0YJK1
ENSG00000126214ENST00000634686Q07866

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate KTN1REACTOMER-HSA-5625970
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD17549067
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD17549067
PA450085irinotecanChemicalClinicalAnnotationassociatedPD17549067
PA450198leucovorinChemicalClinicalAnnotationassociatedPD17549067

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
252099982014Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins.41
213858392011Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1.28
224704972012Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms.19
178252992007The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2.17
124752392002The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23.16
244975052014Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
206010962010Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma.10
176530412007Variability in the kinesin light chain 1 gene may influence risk of age-related cataract.9

Citation

Dessen P

KLC1 (kinesin light chain 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49869/klc1