KLC4 (kinesin light chain 4)

2014-11-01  

Identity

HGNC
KLC4
LOCATION
6p21.1
LOCUSID
89953
ALIAS
KNSL8,bA387M24.3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 89953
HGNC: 21624
Ensembl: ENSG00000137171

Variants:

dbSNP: 89953
ClinVar: 89953
TCGA: ENSG00000137171
COSMIC: KLC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137171ENST00000259708Q9NSK0
ENSG00000137171ENST00000347162Q9NSK0
ENSG00000137171ENST00000347162A0A024RCZ8
ENSG00000137171ENST00000394056Q9NSK0
ENSG00000137171ENST00000394056A0A024RCZ8
ENSG00000137171ENST00000453940Q9NSK0
ENSG00000137171ENST00000458460Q9NSK0
ENSG00000137171ENST00000460283C9JQU1
ENSG00000137171ENST00000467906Q9NSK0
ENSG00000137171ENST00000469987H7C4M1
ENSG00000137171ENST00000470728C9J8T5
ENSG00000137171ENST00000472792C9JXT5
ENSG00000137171ENST00000479388Q9NSK0
ENSG00000137171ENST00000479388A0A024RCZ8
ENSG00000137171ENST00000479632C9JZE5
ENSG00000137171ENST00000481499F8WCA4
ENSG00000137171ENST00000481888C9K0D5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate KTN1REACTOMER-HSA-5625970
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208183312010Insight into the molecular mechanism of the multitasking kinesin-8 motor.33
264239252015Hereditary spastic paraplegia with recessive trait caused by mutation in KLC4 gene.2

Citation

Dessen P

KLC4 (kinesin light chain 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64945/klc4