KLF15 (Kruppel like factor 15)

2016-04-01  

Identity

HGNC
KLF15
LOCATION
3q21.3
LOCUSID
28999
ALIAS
KKLF

Other Information

Locus ID:

NCBI: 28999
MIM: 606465
HGNC: 14536
Ensembl: ENSG00000163884

Variants:

dbSNP: 28999
ClinVar: 28999
TCGA: ENSG00000163884
COSMIC: KLF15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163884ENST00000296233Q9UIH9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
174382892007Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy.72
224050692012Klf15 orchestrates circadian nitrogen homeostasis.47
203753652010Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation.46
224932572012Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.45
244072922014Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism.45
224934832012Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation.40
185862632008The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts.37
209569752011DNA binding-dependent glucocorticoid receptor activity promotes adipogenesis via Krüppel-like factor 15 gene expression.36
212579222011Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness.33
239994302013Kruppel-like factor 15 is critical for vascular inflammation.28

Citation

Dessen P

KLF15 (Kruppel like factor 15)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55712/klf15