KLF8 (Kruppel like factor 8)

2007-02-01  

Identity

HGNC
KLF8
LOCATION
Xp11.21
LOCUSID
11279
ALIAS
BKLF3,ZNF741

Other Information

Locus ID:

NCBI: 11279
MIM: 300286
HGNC: 6351
Ensembl: ENSG00000102349

Variants:

dbSNP: 11279
ClinVar: 11279
TCGA: ENSG00000102349
COSMIC: KLF8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102349ENST00000358094Q05BZ3
ENSG00000102349ENST00000374928O95600
ENSG00000102349ENST00000468660O95600
ENSG00000102349ENST00000468660A0A024R9X4
ENSG00000102349ENST00000640927O95600

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
176711862007Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion.68
211511792011KLF8 promotes human breast cancer cell invasion and metastasis by transcriptional activation of MMP9.58
239189432013DNA methylation signatures for prediction of biochemical recurrence after radical prostatectomy of clinically localized prostate cancer.58
168323432007KLF8 transcription factor participates in oncogenic transformation.45
235040252013KLF8 involves in TGF-beta-induced EMT and promotes invasion and migration in gastric cancer cells.43
183537722008Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells.41
207284492010Up-regulation of Krüppel-like factor 8 promotes tumor invasion and indicates poor prognosis for hepatocellular carcinoma.38
262358742015MiR-135a inhibits migration and invasion and regulates EMT-related marker genes by targeting KLF8 in lung cancer cells.31
160233922005A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element.30
159376682005Single nucleotide polymorphisms in the gene encoding Krüppel-like factor 7 are associated with type 2 diabetes.22

Citation

Dessen P

KLF8 (Kruppel like factor 8)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43804/klf8