KLHDC2 (kelch domain containing 2)

2014-08-01  

Identity

HGNC
KLHDC2
LOCATION
14q21.3
LOCUSID
23588
ALIAS
HCLP-1,HCLP1,LCP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23588
MIM: 611280
HGNC: 20231
Ensembl: ENSG00000165516

Variants:

dbSNP: 23588
ClinVar: 23588
TCGA: ENSG00000165516
COSMIC: KLHDC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165516ENST00000298307Q9Y2U9
ENSG00000165516ENST00000554589G3V3U8
ENSG00000165516ENST00000555443Q9Y2U9
ENSG00000165516ENST00000555739Q9Y2U9
ENSG00000165516ENST00000557247G3V2H2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
305268722018Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase.7
169644372007Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2.6

Citation

Dessen P

KLHDC2 (kelch domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54415/klhdc2