KLK1 (kallikrein 1)

2003-06-01 Affiliation

Identity

HGNC

KLK1

LOCATION

19q13.33

LOCUSID

3816

ALIAS

KLKR,Klk6,hK1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3816
MIM: 147910
HGNC: 6357
Ensembl: ENSG00000167748

Variants:

dbSNP: 3816
ClinVar: 3816
TCGA: ENSG00000167748
COSMIC: KLK1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000167748	ENST00000301420	P06870
ENSG00000167748	ENST00000301420	A0A1R3UCD2
ENSG00000167748	ENST00000593325	M0R318

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Renin-angiotensin system	KEGG	ko04614
Renin-angiotensin system	KEGG	hsa04614
Endocrine and other factor-regulated calcium reabsorption	KEGG	ko04961
Endocrine and other factor-regulated calcium reabsorption	KEGG	hsa04961
Metabolism of proteins	REACTOME	R-HSA-392499
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	REACTOME	R-HSA-381426

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
18725990	2008	Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation.	67
17158887	2007	A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation.	43
17804733	2007	Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion.	43
15611141	2005	Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-Bad.14-3-3 signaling pathways.	38
16129698	2005	Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy.	36
14988406	2004	Role of hyaluronan and reactive oxygen species in tissue kallikrein-mediated epidermal growth factor receptor activation in human airways.	31
20424135	2010	Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.	29
18283336	2008	Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells.	26
23874198	2013	Endothelial cell permeability during hantavirus infection involves factor XII-dependent increased activation of the kallikrein-kinin system.	25

Citation

Dessen P

KLK1 (kallikrein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41075/klk1