KLRC1 (killer cell lectin like receptor C1)

2003-06-01  

Identity

HGNC
LOCATION
12p13.2
LOCUSID
ALIAS
CD159A,NKG2,NKG2A

Other Information

Locus ID:

NCBI: 3821
MIM: 161555
HGNC: 6374
Ensembl: ENSG00000134545

Variants:

dbSNP: 3821
ClinVar: 3821
TCGA: ENSG00000134545
COSMIC: KLRC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134545ENST00000347831P26715
ENSG00000134545ENST00000359151P26715
ENSG00000134545ENST00000408006P26715
ENSG00000134545ENST00000536188F5GYZ0
ENSG00000134545ENST00000543893H0YGB7
ENSG00000134545ENST00000544822P26715

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Antigen processing and presentationKEGGko04612
Natural killer cell mediated cytotoxicityKEGGko04650
Graft-versus-host diseaseKEGGko05332
Antigen processing and presentationKEGGhsa04612
Natural killer cell mediated cytotoxicityKEGGhsa04650
Graft-versus-host diseaseKEGGhsa05332
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10004adalimumabChemicalClinicalAnnotation, VariantAnnotationambiguousPD26453102
PA165107055certolizumab pegolChemicalClinicalAnnotation, VariantAnnotationambiguousPD26453102
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotation, VariantAnnotationambiguousPD26453102
PA449515etanerceptChemicalClinicalAnnotation, VariantAnnotationambiguousPD26453102
PA450428methotrexateChemicalClinicalAnnotation, VariantAnnotationambiguousPD26453102
PA452347glucocorticoidsChemicalClinicalAnnotation, VariantAnnotationambiguousPD26453102
PA452639infliximabChemicalClinicalAnnotation, VariantAnnotationambiguousPD26453102

References

Pubmed IDYearTitleCitations
206969442010Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education.224
155283432004Negative regulation of NK cell activities by inhibitory receptor CD94/NKG2A leads to altered NK cell-induced modulation of dendritic cell functions in chronic hepatitis C virus infection.76
156872352005NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect.76
207005042010NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs.70
183321822008CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.67
124610762002A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.65
184486742008Structural basis for NKG2A/CD94 recognition of HLA-E.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
189810882008Interaction of monocytes with NK cells upon Toll-like receptor-induced expression of the NKG2D ligand MICA.46
123877422002TCR specificity dictates CD94/NKG2A expression by human CTL.40

Citation

Dessen P

KLRC1 (killer cell lectin like receptor C1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41090/klrc1