KLRF1 (killer cell lectin like receptor F1)

2014-11-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
CLEC5C,NKp80

Other Information

Locus ID:

NCBI: 51348
MIM: 605029
HGNC: 13342
Ensembl: ENSG00000150045

Variants:

dbSNP: 51348
ClinVar: 51348
TCGA: ENSG00000150045
COSMIC: KLRF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150045ENST00000279545Q9NZS2
ENSG00000150045ENST00000354855Q9NZS2
ENSG00000150045ENST00000537723Q4KN30
ENSG00000150045ENST00000545196Q4KN05
ENSG00000150045ENST00000612321Q9NZS2
ENSG00000150045ENST00000617793Q4KMZ4
ENSG00000150045ENST00000617889Q9NZS2

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

References

Pubmed IDYearTitleCitations
273731652016NKp80 Defines a Critical Step during Human Natural Killer Cell Development.28
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
211496062011Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity.17
189228552009NKp80 defines and stimulates a reactive subset of CD8 T cells.16
239298562013Genetically coupled receptor-ligand pair NKp80-AICL enables autonomous control of human NK cell responses.12
262779002017Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy.11
227153682012Effect of recombinant cytokines on the expression of natural killer cell receptors from patients with TB or/and HIV infection.6
236094472013Attenuated natural killer (NK) cell activation through C-type lectin-like receptor NKp80 is due to an anomalous hemi-immunoreceptor tyrosine-based activation motif (HemITAM) with impaired Syk kinase recruitment capacity.3

Citation

Dessen P

KLRF1 (killer cell lectin like receptor F1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64989/klrf1