Identity
HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
2F1,CLEC15A,MAFA,MAFA-2F1,MAFA-L,MAFA-LIKE
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10219
MIM: 604874
HGNC: 6380
Ensembl: ENSG00000139187
Variants:
dbSNP: 10219
ClinVar: 10219
TCGA: ENSG00000139187
COSMIC: KLRG1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000139187 | ENST00000266551 | Q96E93 |
| ENSG00000139187 | ENST00000356986 | Q96E93 |
| ENSG00000139187 | ENST00000539240 | F5H207 |
| ENSG00000139187 | ENST00000543895 | F5H8E3 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Adaptive Immune System | REACTOME | R-HSA-1280218 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | REACTOME | R-HSA-198933 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38652959 | 2024 | Expression of HLA-DR and KLRG1 enhances the cytotoxic potential and cytokine secretion capacity of CD3(+) T cells in tuberculosis patients. | 1 |
| 38776335 | 2024 | KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in patients with chronic hepatitis B. | 0 |
| 38652959 | 2024 | Expression of HLA-DR and KLRG1 enhances the cytotoxic potential and cytokine secretion capacity of CD3(+) T cells in tuberculosis patients. | 1 |
| 38776335 | 2024 | KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in patients with chronic hepatitis B. | 0 |
| 36876466 | 2023 | KLRG1 is reduced on NK cells in SLE patients, inversely correlates with disease activity and is modulated by hydroxychloroquine in vitro. | 3 |
| 37741278 | 2023 | KLRG1 expression on natural killer cells is associated with HIV persistence, and its targeting promotes the reduction of the viral reservoir. | 4 |
| 36876466 | 2023 | KLRG1 is reduced on NK cells in SLE patients, inversely correlates with disease activity and is modulated by hydroxychloroquine in vitro. | 3 |
| 37741278 | 2023 | KLRG1 expression on natural killer cells is associated with HIV persistence, and its targeting promotes the reduction of the viral reservoir. | 4 |
| 33401997 | 2022 | Expression and Clinical Significance of KLRG1 and 2B4 on T Cells in the Peripheral Blood and Tumour of Patients with Cervical Cancer. | 3 |
| 35413989 | 2022 | Increased expression of TIGIT and KLRG1 correlates with impaired CD56(bright) NK cell immunity in HPV16-related cervical intraepithelial neoplasia. | 6 |
| 36096526 | 2022 | N-cadherin protects oral cancer cells from NK cell killing in the circulation by inducing NK cell functional exhaustion via the KLRG1 receptor. | 9 |
| 33401997 | 2022 | Expression and Clinical Significance of KLRG1 and 2B4 on T Cells in the Peripheral Blood and Tumour of Patients with Cervical Cancer. | 3 |
| 35413989 | 2022 | Increased expression of TIGIT and KLRG1 correlates with impaired CD56(bright) NK cell immunity in HPV16-related cervical intraepithelial neoplasia. | 6 |
| 36096526 | 2022 | N-cadherin protects oral cancer cells from NK cell killing in the circulation by inducing NK cell functional exhaustion via the KLRG1 receptor. | 9 |
| 33900816 | 2021 | Development of Antihuman Killer Cell Lectin-Like Receptor Subfamily G Member 1 Monoclonal Antibodies for Flow Cytometry. | 1 |
Citation
Dessen P
KLRG1 (killer cell lectin like receptor G1)
Atlas Genet Cytogenet Oncol Haematol. 2004-06-01
Online version: http://atlasgeneticsoncology.org/gene/42906/klrg1
