KMO (kynurenine 3-monooxygenase)

2016-05-01  

Identity

HGNC
LOCATION
1q43
LOCUSID
ALIAS
dJ317G22.1
FUSION GENES

Other Information

Locus ID:

NCBI: 8564
MIM: 603538
HGNC: 6381
Ensembl: ENSG00000117009

Variants:

dbSNP: 8564
ClinVar: 8564
TCGA: ENSG00000117009
COSMIC: KMO

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117009ENST00000366555H0Y320
ENSG00000117009ENST00000366557O15229
ENSG00000117009ENST00000366558O15229
ENSG00000117009ENST00000366559O15229

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Tryptophan metabolismKEGGko00380
Tryptophan metabolismKEGGhsa00380
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Tryptophan catabolismREACTOMER-HSA-71240
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
217272512011Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes.59
216930932012Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls.31
234594682014The KMO allele encoding Arg452 is associated with psychotic features in bipolar disorder type 1, and with increased CSF KYNA level and reduced KMO expression.30
159500642005Localisation of indoleamine 2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: implications for role of the kynurenine pathway in pregnancy.25
167162062006Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population.21
167162062006Association study between kynurenine 3-monooxygenase gene and schizophrenia in the Japanese population.21
265898322016Kynurenine-3-monooxygenase: a review of structure, mechanism, and inhibitors.19
260995642015Prognostic significance of kynurenine 3-monooxygenase and effects on proliferation, migration, and invasion of human hepatocellular carcinoma.18
254649172014Influence of kynurenine 3-monooxygenase (KMO) gene polymorphism on cognitive function in schizophrenia.12
210302132011Kynurenine 3-monooxygenase (KMO) polymorphisms in schizophrenia: an association study.10

Citation

Dessen P

KMO (kynurenine 3-monooxygenase)

Atlas Genet Cytogenet Oncol Haematol. 2016-05-01

Online version: http://atlasgeneticsoncology.org/gene/55782/kmo