KRT14 (keratin 14)

2008-05-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
CK14,EBS3,EBS4,K14,NFJ
FUSION GENES

Other Information

Locus ID:

NCBI: 3861
MIM: 148066
HGNC: 6416
Ensembl: ENSG00000186847

Variants:

dbSNP: 3861
ClinVar: 3861
TCGA: ENSG00000186847
COSMIC: KRT14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186847ENST00000167586P02533

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
7000
8000
9000

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
268310772016Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters.165
194619982009An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate.72
219005002011Novel function of keratins 5 and 14 in proliferation and differentiation of stratified epithelial cells.62
171599132007A functional enhancer of keratin14 is a direct transcriptional target of deltaNp63.44
196518902009Self-organization of keratin intermediate filaments into cross-linked networks.33
222779432012Defining keratin protein function in skin epithelia: epidermolysis bullosa simplex and its aftermath.31
169608092006Naegeli-Franceschetti-Jadassohn syndrome and dermatopathia pigmentosa reticularis: two allelic ectodermal dysplasias caused by dominant mutations in KRT14.21
121655432002A spontaneous CD8 T cell-dependent autoimmune disease to an antigen expressed under the human keratin 14 promoter.19
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
288884692017Cut and Paste: Efficient Homology-Directed Repair of a Dominant Negative KRT14 Mutation via CRISPR/Cas9 Nickases.17

Citation

Dessen P

KRT14 (keratin 14)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50134/krt14