KRT4 (keratin 4)

2011-07-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
CK-4,CK4,CYK4,K4,WSN1
FUSION GENES

Other Information

Locus ID:

NCBI: 3851
MIM: 123940
HGNC: 6441
Ensembl: ENSG00000170477

Variants:

dbSNP: 3851
ClinVar: 3851
TCGA: ENSG00000170477
COSMIC: KRT4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170477ENST00000548097F8VX05
ENSG00000170477ENST00000551956P19013
ENSG00000170477ENST00000552668F8VZR6

Expression (GTEx)

0
5000
10000
15000
20000
25000

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
194683002009Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.104
194683022009Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.88
177094122007The surface protein Srr-1 of Streptococcus agalactiae binds human keratin 4 and promotes adherence to epithelial HEp-2 cells.62
213710752011Down-regulation of keratin 4 and keratin 13 expression in oral squamous cell carcinoma and epithelial dysplasia: a clue for histopathogenesis.19
214987182011Fascin and CK4 as biomarkers for esophageal squamous cell carcinoma.17
195150432009Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis plane wart-type lesions.4
256031462015Structure of KRT4 binding domain of Srr-1 from Streptococcus agalactiae reveals a novel β-sheet complementation.4
231826992013Mutation of keratin 4 gene causing white sponge nevus in a Japanese family.3
189920232009Two new mutations in the keratin 4 gene causing oral white sponge nevus in Chinese family.2
294766682018Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus.0

Citation

Dessen P

KRT4 (keratin 4)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52270/krt4