KRT6A (keratin 6A)

2007-09-01  

Identity

HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
CK-6C,CK-6E,CK6A,CK6C,CK6D,K6A,K6C,K6D,KRT6C,KRT6D,PC3
FUSION GENES

Other Information

Locus ID:

NCBI: 3853
MIM: 148041
HGNC: 6443
Ensembl: ENSG00000205420

Variants:

dbSNP: 3853
ClinVar: 3853
TCGA: ENSG00000205420
COSMIC: KRT6A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205420ENST00000330722P02538
ENSG00000205420ENST00000330722A0A0S2Z428

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
7000
8000

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
KeratinizationREACTOMER-HSA-6805567

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176503142007Use of immunohistochemical markers can refine prognosis in triple negative breast cancer.112
197209112009Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel.79
230063282012Cytokeratins mediate epithelial innate defense through their antimicrobial properties.36
243269842014Cytokeratin 5/6, c-Met expressions, and PTEN loss prognostic indicators in triple-negative breast cancer.24
230758942012The diagnostic utility of D2-40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology.16
222646702012A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita.15
196996132009Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients.8
177197472007A spectrum of mutations in keratins K6a, K16 and K17 causing pachyonychia congenita.7
291918482018Keratin 6a reorganization for ubiquitin-proteasomal processing is a direct antimicrobial response.7
204033712010Aberrant heterodimerization of keratin 16 with keratin 6A in HaCaT keratinocytes results in diminished cellular migration.5

Citation

Dessen P

KRT6A (keratin 6A)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49748/krt6a