Atlas of Genetics and Cytogenetics in Oncology and Haematology

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LAG3 (lymphocyte activating 3)

Identity

Alias_nameslymphocyte-activation gene 3
Alias_symbol (synonym)CD223
Other alias
HGNC (Hugo) LAG3
LocusID (NCBI) 3902
Atlas_Id 41111
Location 12p13.31  [Link to chromosome band 12p13]
Location_base_pair Starts at 6772504 and ends at 6778455 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MED13L (12q24.21) / LAG3 (12p13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  inv(12)(p13q24) MED13L/LAG3

External links

Nomenclature
HGNC (Hugo)LAG3   6476
Cards
Entrez_Gene (NCBI)LAG3  3902  lymphocyte activating 3
AliasesCD223
GeneCards (Weizmann)LAG3
Ensembl hg19 (Hinxton)ENSG00000089692 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000089692 [Gene_View]  ENSG00000089692 [Sequence]  chr12:6772504-6778455 [Contig_View]  LAG3 [Vega]
ICGC DataPortalENSG00000089692
TCGA cBioPortalLAG3
AceView (NCBI)LAG3
Genatlas (Paris)LAG3
WikiGenes3902
SOURCE (Princeton)LAG3
Genetics Home Reference (NIH)LAG3
Genomic and cartography
GoldenPath hg38 (UCSC)LAG3  -     chr12:6772504-6778455 +  12p13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LAG3  -     12p13.31   [Description]    (hg19-Feb_2009)
GoldenPathLAG3 - 12p13.31 [CytoView hg19]  LAG3 - 12p13.31 [CytoView hg38]
ImmunoBaseENSG00000089692
Mapping of homologs : NCBILAG3 [Mapview hg19]  LAG3 [Mapview hg38]
OMIM153337   
Gene and transcription
Genbank (Entrez)A21353 AA687676 AI274900 AK292104 BC037962
RefSeq transcript (Entrez)NM_002286
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LAG3
Cluster EST : UnigeneHs.409523 [ NCBI ]
CGAP (NCI)Hs.409523
Alternative Splicing GalleryENSG00000089692
Gene ExpressionLAG3 [ NCBI-GEO ]   LAG3 [ EBI - ARRAY_EXPRESS ]   LAG3 [ SEEK ]   LAG3 [ MEM ]
Gene Expression Viewer (FireBrowse)LAG3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3902
GTEX Portal (Tissue expression)LAG3
Human Protein AtlasENSG00000089692-LAG3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18627   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP18627  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18627
Splice isoforms : SwissVarP18627
PhosPhoSitePlusP18627
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    IL-1_rcpt_fam   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)LAG3
DMDM Disease mutations3902
Blocks (Seattle)LAG3
SuperfamilyP18627
Human Protein Atlas [tissue]ENSG00000089692-LAG3 [tissue]
Peptide AtlasP18627
HPRD01077
IPIIPI00000881   IPI00788890   
Protein Interaction databases
DIP (DOE-UCLA)P18627
IntAct (EBI)P18627
FunCoupENSG00000089692
BioGRIDLAG3
STRING (EMBL)LAG3
ZODIACLAG3
Ontologies - Pathways
QuickGOP18627
Ontology : AmiGOadaptive immune response  plasmacytoid dendritic cell activation  antigen binding  transmembrane signaling receptor activity  protein binding  extracellular region  plasma membrane  cell surface receptor signaling pathway  external side of plasma membrane  integral component of membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  MHC class II protein binding  MHC class II protein binding  negative regulation of interleukin-2 biosynthetic process  negative regulation of regulatory T cell differentiation  positive regulation of natural killer cell mediated cytotoxicity  regulation of immune response  
Ontology : EGO-EBIadaptive immune response  plasmacytoid dendritic cell activation  antigen binding  transmembrane signaling receptor activity  protein binding  extracellular region  plasma membrane  cell surface receptor signaling pathway  external side of plasma membrane  integral component of membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  MHC class II protein binding  MHC class II protein binding  negative regulation of interleukin-2 biosynthetic process  negative regulation of regulatory T cell differentiation  positive regulation of natural killer cell mediated cytotoxicity  regulation of immune response  
NDEx NetworkLAG3
Atlas of Cancer Signalling NetworkLAG3
Wikipedia pathwaysLAG3
Orthology - Evolution
OrthoDB3902
GeneTree (enSembl)ENSG00000089692
Phylogenetic Trees/Animal Genes : TreeFamLAG3
HOGENOMP18627
Homologs : HomoloGeneLAG3
Homology/Alignments : Family Browser (UCSC)LAG3
Gene fusions - Rearrangements
Fusion : MitelmanMED13L/LAG3 [12q24.21/12p13.31]  [inv(12)(p13q24)]  
Fusion : QuiverLAG3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLAG3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LAG3
dbVarLAG3
ClinVarLAG3
1000_GenomesLAG3 
Exome Variant ServerLAG3
ExAC (Exome Aggregation Consortium)ENSG00000089692
GNOMAD BrowserENSG00000089692
Varsome BrowserLAG3
Genetic variants : HAPMAP3902
Genomic Variants (DGV)LAG3 [DGVbeta]
DECIPHERLAG3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLAG3 
Mutations
ICGC Data PortalLAG3 
TCGA Data PortalLAG3 
Broad Tumor PortalLAG3
OASIS PortalLAG3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLAG3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLAG3
Mutations and Diseases : HGMDLAG3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LAG3
DgiDB (Drug Gene Interaction Database)LAG3
DoCM (Curated mutations)LAG3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LAG3 (select a term)
intoGenLAG3
Cancer3DLAG3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM153337   
Orphanet
DisGeNETLAG3
MedgenLAG3
Genetic Testing Registry LAG3
NextProtP18627 [Medical]
TSGene3902
GENETestsLAG3
Target ValidationLAG3
Huge Navigator LAG3 [HugePedia]
snp3D : Map Gene to Disease3902
BioCentury BCIQLAG3
ClinGenLAG3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3902
Chemical/Pharm GKB GenePA30265
Clinical trialLAG3
Miscellaneous
canSAR (ICR)LAG3 (select the gene name)
DataMed IndexLAG3
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLAG3
EVEXLAG3
GoPubMedLAG3
iHOPLAG3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:50:11 CET 2019
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