LAIR1 (leukocyte associated immunoglobulin like receptor 1)

2010-04-01  

Identity

HGNC
LAIR1
LOCATION
19q13.42
LOCUSID
3903
ALIAS
CD305,LAIR-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3903
MIM: 602992
HGNC: 6477
Ensembl: ENSG00000167613

Variants:

dbSNP: 3903
ClinVar: 3903
TCGA: ENSG00000167613
COSMIC: LAIR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167613ENST00000348231Q6GTX8
ENSG00000167613ENST00000391741W4VSQ5
ENSG00000167613ENST00000391742Q6GTX8
ENSG00000167613ENST00000391743A8MZ84
ENSG00000167613ENST00000418556F8WC07
ENSG00000167613ENST00000420483F2Z3B9
ENSG00000167613ENST00000434277D3YTC8
ENSG00000167613ENST00000436513F2Z3B9
ENSG00000167613ENST00000438193C9IZB2
ENSG00000167613ENST00000474878Q6GTX8
ENSG00000167613ENST00000622064A0A087X137

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
167547212006Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1.79
180636952008The inhibitory collagen receptor LAIR-1 (CD305).77
230936732012C1q limits dendritic cell differentiation and activation by engaging LAIR-1.57
267008142016A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.42
259151252015The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development.35
182090622008The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction.32
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
193452632009Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III.26
211514952010The immune inhibitory receptor LAIR-1 is highly expressed by plasmacytoid dendritic cells and acts complementary with NKp44 to control IFNα production.25
291861162017Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors.25

Citation

Dessen P

LAIR1 (leukocyte associated immunoglobulin like receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51428/lair1