LAIR2 (leukocyte associated immunoglobulin like receptor 2)

2014-11-01 Affiliation

Identity

HGNC

LAIR2

LOCATION

19q13.42

LOCUSID

3904

ALIAS

CD306

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3904
MIM: 602993
HGNC: 6478
Ensembl: ENSG00000167618

Variants:

dbSNP: 3904
ClinVar: 3904
TCGA: ENSG00000167618
COSMIC: LAIR2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000167618	ENST00000301202	Q6ISS4
ENSG00000167618	ENST00000351841	Q6ISS4
ENSG00000167618	ENST00000412608	C9JFQ0
ENSG00000167618	ENST00000610651	A0A087X1V4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933

References

Pubmed ID	Year	Title	Citations
18209062	2008	The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction.	32
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
19345263	2009	Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III.	26
20730098	2010	Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member.	8
23332415	2013	LAIR2-expressing extravillous trophoblasts associate with maternal spiral arterioles undergoing physiologic conversion.	6
26721477	2016	Differential gene expression levels might explain association of LAIR2 polymorphisms with pemphigus.	5
23691008	2013	Serum LAIR-2 is increased in autoimmune thyroid diseases.	4
24192271	2014	Inhibition of the classical and lectin pathway of the complement system by recombinant LAIR-2.	4
22294640	2012	A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis.	3
30216441	2019	Screening the full leucocyte receptor complex genomic region revealed associations with pemphigus that might be explained by gene regulation.	1

Citation

Dessen P

LAIR2 (leukocyte associated immunoglobulin like receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/65161/lair2