LALBA (lactalbumin alpha)

2007-02-01  

Identity

HGNC
LALBA
LOCATION
12q13.11
LOCUSID
3906
ALIAS
LYZG

Other Information

Locus ID:

NCBI: 3906
MIM: 149750
HGNC: 6480
Ensembl: ENSG00000167531

Variants:

dbSNP: 3906
ClinVar: 3906
TCGA: ENSG00000167531
COSMIC: LALBA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167531ENST00000301046P00709
ENSG00000167531ENST00000301046A0A080YV01
ENSG00000167531ENST00000549817F8VWU1

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Galactose metabolismKEGGko00052
Galactose metabolismKEGGhsa00052
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Lactose synthesisREACTOMER-HSA-5653890

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
lactating breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
230053412012The small heat-shock protein αB-crystallin uses different mechanisms of chaperone action to prevent the amorphous versus fibrillar aggregation of α-lactalbumin.20
146277402003Lipids as cofactors in protein folding: stereo-specific lipid-protein interactions are required to form HAMLET (human alpha-lactalbumin made lethal to tumor cells).16
190389212008Expression and characterization of bioactive recombinant human alpha-lactalbumin in the milk of transgenic cloned cows.15
227354922012Effects of macromolecular crowding on the structural stability of human α-lactalbumin.14
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
159562052005Multiple subsets of side-chain packing in partially folded states of alpha-lactalbumins.11
146277392003Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells).10
128601372003Structural characterisation of the human alpha-lactalbumin molten globule at high temperature.9
199687172010The oleic acid complexes of proteolytic fragments of alpha-lactalbumin display apoptotic activity.8
150754032004Conformational analysis of HAMLET, the folding variant of human alpha-lactalbumin associated with apoptosis.6

Citation

Dessen P

LALBA (lactalbumin alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43605/lalba