LAMB1 (laminin subunit beta 1)

2003-06-01  

Identity

HGNC
LOCATION
7q31.1
LOCUSID
ALIAS
CLM,LIS5
FUSION GENES

Other Information

Locus ID:

NCBI: 3912
MIM: 150240
HGNC: 6486
Ensembl: ENSG00000091136

Variants:

dbSNP: 3912
ClinVar: 3912
TCGA: ENSG00000091136
COSMIC: LAMB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091136ENST00000222399P07942
ENSG00000091136ENST00000393559E9PCS6
ENSG00000091136ENST00000393560E7EPA6
ENSG00000091136ENST00000393561G3XAI2
ENSG00000091136ENST00000439976C9J296

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
ECM-receptor interactionKEGGko04512
Small cell lung cancerKEGGko05222
Focal adhesionKEGGhsa04510
ECM-receptor interactionKEGGhsa04512
Pathways in cancerKEGGhsa05200
Small cell lung cancerKEGGhsa05222
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Signal TransductionREACTOMER-HSA-162582
Extracellular matrix organizationREACTOMER-HSA-1474244
Laminin interactionsREACTOMER-HSA-3000157
Non-integrin membrane-ECM interactionsREACTOMER-HSA-3000171
ECM proteoglycansREACTOMER-HSA-3000178
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Signaling by METREACTOMER-HSA-6806834
MET promotes cell motilityREACTOMER-HSA-8875878
MET activates PTK2 signalingREACTOMER-HSA-8874081

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
354364112022Lamin B1 is a potential therapeutic target and prognostic biomarker for hepatocellular carcinoma.7
354456272022Evaluation of JUN, FN1 and LAMB1 polymorphisms in pterygium in a Chinese Han population.0
357636702022RNA Helicase DDX24 Stabilizes LAMB1 to Promote Hepatocellular Carcinoma Progression.5
358435862022Compound variants of FKTN, POMGNT1, and LAMB1 gene identified by prenatal whole-exome sequencing in three fetuses with congenital hydrocephalus.0
354364112022Lamin B1 is a potential therapeutic target and prognostic biomarker for hepatocellular carcinoma.7
354456272022Evaluation of JUN, FN1 and LAMB1 polymorphisms in pterygium in a Chinese Han population.0
357636702022RNA Helicase DDX24 Stabilizes LAMB1 to Promote Hepatocellular Carcinoma Progression.5
358435862022Compound variants of FKTN, POMGNT1, and LAMB1 gene identified by prenatal whole-exome sequencing in three fetuses with congenital hydrocephalus.0
334351612021Upregulation of LAMB1 via ERK/c-Jun Axis Promotes Gastric Cancer Growth and Motility.22
337848902021LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer.10
346061152021End-Truncated LAMB1 Causes a Hippocampal Memory Defect and a Leukoencephalopathy.5
334351612021Upregulation of LAMB1 via ERK/c-Jun Axis Promotes Gastric Cancer Growth and Motility.22
337848902021LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer.10
346061152021End-Truncated LAMB1 Causes a Hippocampal Memory Defect and a Leukoencephalopathy.5
320857982020CRISPR-Cas9-mediated labelling of the C-terminus of human laminin β1 leads to secretion inhibition.3

Citation

Dessen P

LAMB1 (laminin subunit beta 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41115/lamb1