LAMP1 (lysosomal associated membrane protein 1)

2003-06-01  

Identity

HGNC
LAMP1
LOCATION
13q34
LOCUSID
3916
ALIAS
CD107a,LAMPA,LGP120
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3916
MIM: 153330
HGNC: 6499
Ensembl: ENSG00000185896

Variants:

dbSNP: 3916
ClinVar: 3916
TCGA: ENSG00000185896
COSMIC: LAMP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185896ENST00000332556P11279
ENSG00000185896ENST00000332556A0A024RDY3

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
LysosomeKEGGko04142
LysosomeKEGGhsa04142
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
188355982009Relationship between CD107a expression and cytotoxic activity.105
249700852014Virus entry. Lassa virus entry requires a trigger-induced receptor switch.100
167781442006Analysis of natural killer-cell function in familial hemophagocytic lymphohistiocytosis (FHL): defective CD107a surface expression heralds Munc13-4 defect and discriminates between genetic subtypes of the disease.57
280550072017Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration.52
268490492016Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike.40
259725332015Molecular Mechanism for LAMP1 Recognition by Lassa Virus.37
157443402005CD56dimCD16neg cells are responsible for natural cytotoxicity against tumor targets.36
249165092014Synergistic defects of different molecules in the cytotoxic pathway lead to clinical familial hemophagocytic lymphohistiocytosis.35
238471952013Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage.34
236328902013LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity.32

Citation

Dessen P

LAMP1 (lysosomal associated membrane protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41121/lamp1