LAMP2 (lysosomal associated membrane protein 2)

2003-06-01 Affiliation

Identity

HGNC

LAMP2

LOCATION

Xq24

LOCUSID

3920

ALIAS

CD107b,DND,LAMP-2,LAMPB,LGP-96,LGP110

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3920
MIM: 309060
HGNC: 6501
Ensembl: ENSG00000005893

Variants:

dbSNP: 3920
ClinVar: 3920
TCGA: ENSG00000005893
COSMIC: LAMP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000005893	ENST00000200639	P13473
ENSG00000005893	ENST00000371335	P13473
ENSG00000005893	ENST00000434600	P13473
ENSG00000005893	ENST00000486593	H0YCG2

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Autophagy - animal	KEGG	ko04140
Autophagy - animal	KEGG	hsa04140
Lysosome	KEGG	ko04142
Lysosome	KEGG	hsa04142
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Response to elevated platelet cytosolic Ca2+	REACTOME	R-HSA-76005
Platelet degranulation	REACTOME	R-HSA-114608
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15673802	2005	Glycogen storage diseases presenting as hypertrophic cardiomyopathy.	111
15894275	2005	Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens.	110
18403758	2008	Shared genetic causes of cardiac hypertrophy in children and adults.	100
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19362087	2009	Impaired autolysosome formation correlates with Lamp-2 depletion: role of apoptosis, autophagy, and necrosis in pancreatitis.	81
18550537	2008	Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy.	75
23492776	2013	Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease.	71
26658462	2015	Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane.	46
23071649	2012	The role of chaperone-mediated autophagy in huntingtin degradation.	41
25594542	2015	Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease.	40

Citation

Dessen P

LAMP2 (lysosomal associated membrane protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41122/lamp2