LAMTOR5 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5)

2012-10-01 Affiliation

Identity

HGNC

LAMTOR5

LOCATION

1p13.3

LOCUSID

10542

ALIAS

HBXIP,XIP

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10542
MIM: 608521
HGNC: 17955
Ensembl: ENSG00000134248

Variants:

dbSNP: 10542
ClinVar: 10542
TCGA: ENSG00000134248
COSMIC: LAMTOR5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000134248	ENST00000256644	A0A0C4DGV4
ENSG00000134248	ENST00000474861	E9PLX3
ENSG00000134248	ENST00000483260	E9PLX3
ENSG00000134248	ENST00000602318	O43504
ENSG00000134248	ENST00000602858	R4GMU8
ENSG00000134248	ENST00000614544	A0A0C4DGV4

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
mTOR signaling pathway	KEGG	ko04150
mTOR signaling pathway	KEGG	hsa04150
Hepatitis B	KEGG	hsa05161
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
PI3K Cascade	REACTOME	R-HSA-109704
PKB-mediated events	REACTOME	R-HSA-109703
mTOR signalling	REACTOME	R-HSA-165159
mTORC1-mediated signalling	REACTOME	R-HSA-166208
Energy dependent regulation of mTOR by LKB1-AMPK	REACTOME	R-HSA-380972
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Metabolic Genes	REACTOME	R-HSA-5628897
Cellular responses to stress	REACTOME	R-HSA-2262752
Macroautophagy	REACTOME	R-HSA-1632852

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22980980	2012	Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.	336
12773388	2003	HBXIP functions as a cofactor of survivin in apoptosis suppression.	122
29174803	2018	HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g.	65
26143443	2015	HBx relieves chromatin-mediated transcriptional repression of hepatitis B viral cccDNA involving SETDB1 histone methyltransferase.	45
26719542	2016	HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.	40
21343296	2011	miR-520b regulates migration of breast cancer cells by targeting hepatitis B X-interacting protein and interleukin-8.	39
23266610	2013	MicroRNA-501 promotes HBV replication by targeting HBXIP.	35
22740693	2012	The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells.	33
17050029	2006	Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma.	27
17428866	2007	Hepatitis B virus X protein stimulates the mitochondrial translocation of Raf-1 via oxidative stress.	27

Citation

Dessen P

LAMTOR5 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5)

Atlas Genet Cytogenet Oncol Haematol. 2012-10-01

Online version: http://atlasgeneticsoncology.org/gene/47590/lamtor5