LANCL2 (LanC like 2)

2014-08-01  

Identity

HGNC
LANCL2
LOCATION
7p11.2
LOCUSID
55915
ALIAS
GPR69B,TASP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55915
MIM: 612919
HGNC: 6509
Ensembl: ENSG00000132434

Variants:

dbSNP: 55915
ClinVar: 55915
TCGA: ENSG00000132434
COSMIC: LANCL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132434ENST00000254770Q9NS86
ENSG00000132434ENST00000452107H7BZ40

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
196670682009LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells.34
252735592014Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt.20
205126042011Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics.17
125663192003Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism.14
220374582011Binding of abscisic acid to human LANCL2.14
272222872016G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2.10
117621912001Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family.6
294211902018Identification of a high affinity binding site for abscisic acid on human lanthionine synthetase component C-like protein 2.1

Citation

Dessen P

LANCL2 (LanC like 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54418/lancl2