LAP3 (leucine aminopeptidase 3)

2015-02-01  

Identity

HGNC
LOCATION
4p15.32
LOCUSID
ALIAS
HEL-S-106,LAP,LAPEP,PEPS
FUSION GENES

Other Information

Locus ID:

NCBI: 51056
MIM: 170250
HGNC: 18449
Ensembl: ENSG00000002549

Variants:

dbSNP: 51056
ClinVar: 51056
TCGA: ENSG00000002549
COSMIC: LAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000002549ENST00000226299P28838
ENSG00000002549ENST00000509583H0Y983
ENSG00000002549ENST00000513105H0Y9Q1
ENSG00000002549ENST00000606142P28838
ENSG00000002549ENST00000618908P28838

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Glutathione metabolismKEGGko00480
Arginine and proline metabolismKEGGhsa00330
Glutathione metabolismKEGGhsa00480
Metabolic pathwaysKEGGhsa01100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
165131162006Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1.31
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
254532852015LAP3 promotes glioma progression by regulating proliferation, migration and invasion of glioma cells.6
244776622014Overexpression of leucine aminopeptidase 3 contributes to malignant development of human esophageal squamous cell carcinoma.4
251207512014Expression of leucine aminopeptidase 3 (LAP3) correlates with prognosis and malignant development of human hepatocellular carcinoma (HCC).3
304175852019Leucine aminopeptidase 3 promotes migration and invasion of breast cancer cells through upregulation of fascin and matrix metalloproteinases-2/9 expression.3

Citation

Dessen P

LAP3 (leucine aminopeptidase 3)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54993/lap3