LAPTM4B (lysosomal protein transmembrane 4 beta)

2007-02-01  

Identity

HGNC
LAPTM4B
LOCATION
8q22.1
LOCUSID
55353
ALIAS
LAPTM4beta,LC27
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55353
MIM: 613296
HGNC: 13646
Ensembl: ENSG00000104341

Variants:

dbSNP: 55353
ClinVar: 55353
TCGA: ENSG00000104341
COSMIC: LAPTM4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104341ENST00000445593Q86VI4
ENSG00000104341ENST00000517924H0YBN1
ENSG00000104341ENST00000521545Q86VI4
ENSG00000104341ENST00000619747Q86VI4

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
259985672015LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.46
207112372010LAPTM4B: a novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signaling.44
245635152014Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer.33
159111042005The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression.31
220378722011Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells.28
196908862010LAPTM4B-35 overexpression is a risk factor for tumor recurrence and poor prognosis in hepatocellular carcinoma.27
255889452015LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation.27
257140292015miR-188-5p inhibits tumour growth and metastasis in prostate cancer by repressing LAPTM4B expression.27
189494042008LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma.25

Citation

Dessen P

LAPTM4B (lysosomal protein transmembrane 4 beta)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43622/laptm4b