Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7805
MIM: 601476
HGNC: 29612
Ensembl: ENSG00000162511
Variants:
dbSNP: 7805
ClinVar: 7805
TCGA: ENSG00000162511
COSMIC: LAPTM5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000162511 | ENST00000294507 | Q13571 |
| ENSG00000162511 | ENST00000294507 | Q5TBB8 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Lysosome | KEGG | ko04142 |
| Lysosome | KEGG | hsa04142 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38018874 | 2024 | ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma. | 0 |
| 38018874 | 2024 | ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma. | 0 |
| 36037300 | 2023 | Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma. | 14 |
| 36799186 | 2023 | LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway. | 2 |
| 36037300 | 2023 | Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma. | 14 |
| 36799186 | 2023 | LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway. | 2 |
| 35091468 | 2022 | LCDR regulates the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival. | 15 |
| 35157609 | 2022 | Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy. | 9 |
| 35225654 | 2022 | LAPTM5 Restricts HIV-1 Infection in Dendritic Cells and Is Counteracted by Vpr. | 3 |
| 35294039 | 2022 | Spine‑specific downregulation of LAPTM5 expression promotes the progression and spinal metastasis of estrogen receptor‑positive breast cancer by activating glutamine‑dependent mTOR signaling. | 5 |
| 35842443 | 2022 | Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation. | 7 |
| 36037365 | 2022 | LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway. | 4 |
| 35091468 | 2022 | LCDR regulates the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival. | 15 |
| 35157609 | 2022 | Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy. | 9 |
| 35225654 | 2022 | LAPTM5 Restricts HIV-1 Infection in Dendritic Cells and Is Counteracted by Vpr. | 3 |
Citation
Dessen P
LAPTM5 (lysosomal protein transmembrane 5)
Atlas Genet Cytogenet Oncol Haematol. 2012-11-01
Online version: http://atlasgeneticsoncology.org/gene/53018/laptm5
