LARS1 (leucyl-tRNA synthetase 1)

2008-09-01  

Identity

HGNC
LARS1
LOCATION
5q32
LOCUSID
51520
ALIAS
HSPC192,ILFS1,LARS,LEURS,LEUS,LFIS,LRS,PIG44,RNTLS,hr025Cl

Other Information

Locus ID:

NCBI: 51520
MIM: 151350
HGNC: 6512
Ensembl: ENSG00000133706

Variants:

dbSNP: 51520
ClinVar: 51520
TCGA: ENSG00000133706
COSMIC: LARS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133706ENST00000274562Q9P2J5
ENSG00000133706ENST00000394434Q9P2J5
ENSG00000133706ENST00000510191Q9P2J5
ENSG00000133706ENST00000674447B4DER1

Pathways

PathwaySourceExternal ID
Aminoacyl-tRNA biosynthesisKEGGko00970
Aminoacyl-tRNA biosynthesisKEGGhsa00970
Aminoacyl-tRNA biosynthesis, eukaryotesKEGGhsa_M00359
Aminoacyl-tRNA biosynthesis, eukaryotesKEGGM00359
Gene ExpressionREACTOMER-HSA-74160
tRNA AminoacylationREACTOMER-HSA-379724
Cytosolic tRNA aminoacylationREACTOMER-HSA-379716
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Selenoamino acid metabolismREACTOMER-HSA-2408522
SeMet incorporation into proteinsREACTOMER-HSA-2408517

References

Pubmed IDYearTitleCitations
224249462012Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.285
194267432009Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles.30
208052412011Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase.30
226079402012Identification of a mutation in LARS as a novel cause of infantile hepatopathy.30
160554482005The C-terminal appended domain of human cytosolic leucyl-tRNA synthetase is indispensable in its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex.21
244131902014The isolated carboxy-terminal domain of human mitochondrial leucyl-tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human cells.17
289634682017Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.15
184460612008Implication of leucyl-tRNA synthetase 1 (LARS1) over-expression in growth and migration of lung cancer cells detected by siRNA targeted knock-down analysis.13
173785842007A single residue in leucyl-tRNA synthetase affecting amino acid specificity and tRNA aminoacylation.5
197023272009A paradigm shift for the amino acid editing mechanism of human cytoplasmic leucyl-tRNA synthetase.5

Citation

Dessen P

LARS1 (leucyl-tRNA synthetase 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50329/lars1