LAT2 (linker for activation of T cells family member 2)

2010-01-01 Affiliation

Identity

HGNC

LAT2

LOCATION

7q11.23

LOCUSID

7462

ALIAS

HSPC046,LAB,NTAL,WBSCR15,WBSCR5,WSCR5

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7462
MIM: 605719
HGNC: 12749
Ensembl: ENSG00000086730

Variants:

dbSNP: 7462
ClinVar: 7462
TCGA: ENSG00000086730
COSMIC: LAT2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000086730	ENST00000275635	Q9GZY6
ENSG00000086730	ENST00000344995	Q9GZY6
ENSG00000086730	ENST00000361082	F8W947
ENSG00000086730	ENST00000398475	Q9GZY6
ENSG00000086730	ENST00000460943	Q9GZY6
ENSG00000086730	ENST00000465116	C9JDY7
ENSG00000086730	ENST00000470709	C9JXP0
ENSG00000086730	ENST00000475494	C9JA24
ENSG00000086730	ENST00000488266	Q9GZY6

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12486104	2002	Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling.	64
12514734	2003	LAB: a new membrane-associated adaptor molecule in B cell activation.	48
17993265	2008	Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells.	31
17277102	2007	Non-T cell activation linker (NTAL) negatively regulates TREM-1/DAP12-induced inflammatory cytokine production in myeloid cells.	20
15745852	2005	NTAL/LAB and LAT: a balancing act in mast-cell activation and function.	18
15153499	2004	Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding.	17
14722116	2004	The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB.	16
20643813	2011	LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?	10
18645037	2008	Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.	8
23001822	2012	Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity.	7

Citation

Dessen P

LAT2 (linker for activation of T cells family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51310/lat2