LCN1 (lipocalin 1)

2016-04-01 Affiliation

Identity

HGNC

LCN1

LOCATION

9q34.3

LOCUSID

3933

ALIAS

PMFA,TLC,TP,VEGP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3933
MIM: 151675
HGNC: 6525
Ensembl: ENSG00000160349

Variants:

dbSNP: 3933
ClinVar: 3933
TCGA: ENSG00000160349
COSMIC: LCN1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000160349	ENST00000263598	P31025
ENSG00000160349	ENST00000263598	A0A024R8D7
ENSG00000160349	ENST00000371781	P31025
ENSG00000160349	ENST00000371781	A0A024R8D7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
SLC-mediated transmembrane transport	REACTOME	R-HSA-425407
Transport of vitamins, nucleosides, and related molecules	REACTOME	R-HSA-425397
Transport of fatty acids	REACTOME	R-HSA-804914

References

Pubmed ID	Year	Title	Citations
15489503	2005	The 1.8-A crystal structure of human tear lipocalin reveals an extended branched cavity with capacity for multiple ligands.	36
21791187	2011	Tear lipocalin: structure and function.	27
19770509	2009	A new crystal form of human tear lipocalin reveals high flexibility in the loop region and induced fit in the ligand cavity.	18
15461462	2004	Interstrand loops CD and EF act as pH-dependent gates to regulate fatty acid ligand binding in tear lipocalin.	16
19586017	2009	Intracavitary ligand distribution in tear lipocalin by site-directed tryptophan fluorescence.	15
12591932	2003	Antisense down-regulation of lipocalin-interacting membrane receptor expression inhibits cellular internalization of lipocalin-1 in human NT2 cells.	13
21466861	2011	The conserved disulfide bond of human tear lipocalin modulates conformation and lipid binding in a ligand selective manner.	10
17869594	2007	Oligomeric state of lipocalin-1 (LCN1) by multiangle laser light scattering and fluorescence anisotropy decay.	9
26135974	2015	Human Neutrophil Lipocalin as a Superior Diagnostic Means To Distinguish between Acute Bacterial and Viral Infections.	9
11850445	2002	Human lipocalin-1, a physiological scavenger of lipophilic compounds, is produced by corticotrophs of the pituitary gland.	8

Citation

Dessen P

LCN1 (lipocalin 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55716/lcn1